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台灣視網膜色素病變協會
:::左側區塊

Incidence of legal blindness from age-related macular degeneration in denmark:

發佈日期:2012/03/22 am10:22:34

內容:
Incidence of legal blindness from age-related macular degeneration in denmark:
year 2000 to 2010.

Bloch SB, Larsen M, Munch IC.

Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark.

PURPOSE: To report incidence rates of legal blindness from age-related macular
degeneration (AMD) and other causes in Denmark from years 2000 to 2010 in the age
group at risk of AMD aged 50 years and older.

DESIGN: Population-based observational registry study.

METHODS: settings: Membership register of the Danish Association of the Blind,
the primary admission criterion of which is best-corrected visual acuity 0.1
(20/200) or lower in a person`s better-seeing eye. study population: A total of
11 848 incident cases of legal blindness from a population of citizens aged ≥50
years numbering 1.71 million in 2000 and 1.87 million in 2010 with free access to
a single-payer public health care system. main outcome measures: Incidence rates
of legal blindness from AMD from 2000 to 2010.

RESULTS: The incidence rate of legal blindness attributable to AMD in citizens
aged ≥50 years decreased from 52.2 cases per year per 100 000 in 2000 to 25.7
cases per year per 100 000 in 2010, corresponding to a reduction of 50% (95%
confidence interval [CI(95)]: 45%-56%, P < .0001, adjusted for age), the bulk of
the reduction occurring after 2006. The incidence of legal blindness from causes
other than AMD decreased by 33% (CI(95): 21%-44%, P < .0001), most of the
reduction occurring between 2000 and 2006.

CONCLUSION: From 2000 to 2010 the incidence of legal blindness from AMD fell to
half the baseline incidence. The bulk of the reduction occurred after the
introduction of intravitreally injected inhibitors of vascular endothelial growth
factor in 2006.

中文簡述:
目的:從年齡相關性來看黃斑部病變(AMD)和其他原因,發病率從2000年至2010年,在年齡50歲及以上組在AMD的風險。
設計:人口為基礎的觀測註冊表研究
方法:會員註冊丹麥盲人協會,小學的入學標準,這是最佳矯正視力0.1(20/200),或在一個人的好盲低。研究人口:從人口年齡≥50歲,2010年的1.71億編號免費訪問單一付款人的公共衛生保健系統在2000年和187萬的公民總數的11848法律失明的病例。主要成果的措施:從2000年至2010年從AMD公司的法律失明的發病率。
成果:法律失明的發病率在≥50歲的公民佔AMD的下降至52.2例,每年每100萬人,在2000年的25.7例,每年每100萬人在2010年,相應減少50%(95%信心區間[CI(95):45%-56%,P <0.0001,年齡調整),2006年後出現減少的大部分。比AMD的原因其他法律失明的發生率下降了33%(CI(95):21%-44%,磷<0.0001),大部分發生在2000年和2006年之間減少。
結論:從2000年到2010年從AMD公司的法律失明的發生率下降到發病率的一半。在2006年從眼球的玻璃體注射血管內皮生長因子的抑製劑推出後,黃斑部病變發病率有減少的趨勢。