發佈日期：2012/03/22 am10:21:44

內容：
Can genetic risk information for age-related macular degeneration influence
motivation to stop smoking? A pilot study.

Rennie CA, Stinge A, King EA, Sothirachagan S, Osmond C, Lotery AJ.

Department of Ophthalmology, Southampton General Hospital, Southampton, UK.


AIMS: Smoking can increase the risk of macular degeneration and this is more than
additive if a person also has a genetic risk. The purpose of this study was to
examine whether knowledge of genetic risk for age-related macular degeneration
(AMD) could influence motivation to quit smoking.
METHODS: A questionnaire-based study of hypothetical case scenarios given to 49
smokers without AMD. Participants were randomly allocated to a generic risk, high
genetic risk, or low genetic risk of developing AMD scenario.

RESULTS: Forty-seven percent knew of the link between smoking and eye disease. In
all, 76%, 67%, and 46% for the high risk, generic, and low risk groups,
respectively, would rethink quitting (P for trend = 0.082). In all, 67%, 40%, and
38.5%, respectively, would be likely, very likely, or would definitely quit in
the following month (P for trend = 0.023). Few participants (<16% of any group)
were very likely to or would definitely attend a quit smoking session with no
difference across groups. In all, 75.5% of participants would consider taking a
genetic test for AMD.

CONCLUSION: In this pilot study, a trend was seen for the group given high
genetic risk information to be more likely to quit than the generic or low
genetic risk groups. Participants were willing to take a genetic test but further
work is needed to address the cost benefits of routine genetic testing for risk
of AMD. More generic risk information should be given to the public, and health
warnings on cigarette packets that `smoking causes blindness` is a good way to
achieve this.



中文簡述：

目的：吸煙將增加黃斑部病變的風險，同時也有遺傳的風險。本研究的目的是探討年齡相關性黃斑部病變（AMD）的遺傳風險是否能影響戒菸的動機。
方法：吸煙者在一個假設的情況下的所進行的情況問卷調查為基礎的研究。參與者被隨機分配到一個通用的風險，遺傳風險高，或低AMD的情況下開發的遺傳危險。
成果：47%的人知道吸煙與眼部疾病之間的是有關聯的。76％，67％，46％為高風險，（趨勢P=0.082）。67％，40％和38.5％，分別為，將非常可能的，很可能或肯定會在接下來的一個月（趨勢P= 0.023）退出。一些與會者（<16％），很可能或肯定會參加戒菸會話

結論：在這項研究中，一種趨勢被視為給予了高度的遺傳風險信息，更有可能退出比通用或低的遺傳高危險族群。參加者願意接受基因測試，但需要進一步努力，以解決常規AMD的風險基因檢測的成本效益。更通用的風險信息應給公眾，煙包裝上的健康警語，“吸煙導致失明”是一個很好的方式。