發佈日期：2012/03/22 am10:34:02

內容：
miRNAs as potential therapeutic targets for age-related macular degeneration.

Wang S, Koster KM, He Y, Zhou Q.

Department of Ophthalmology, University of Texas Southwestern Medical Center,
5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Since their recent discovery, miRNAs have been shown to play critical roles in a
variety of pathophysiological processes. Such processes include pathological
angiogenesis, the oxidative stress response, immune response and inflammation,
all of which have been shown to have important and interdependent roles in the
pathogenesis and progression of age-related macular degeneration (AMD). Here we
present a brief review of the pathological processes involved in AMD and review
miRNAs and other noncoding RNAs involved in regulating these processes.
Specifically, we discuss several candidate miRNAs that show promise as AMD
therapeutic targets due to their direct involvement in choroidal
neovascularization or retinal pigment epithelium atrophy. We discuss potential
miRNA-based therapeutics and delivery methods for AMD and provide future
directions for the field of miRNA research with respect to AMD. We believe the
future of miRNAs in AMD therapy is promising.

PMID: 22393936 [PubMed - in process]


中文簡述：
最近發現，miRNA的已被證明在各種病理生理過程中發揮關鍵作用。這些過程包括病理的血管生成，氧化刺激反應，免疫反應和癌症反應，所有這些都被證明具有重要的和相互依存的角色在年齡相關性黃斑部病變（AMD）的發病機制和進展。在這裡，我們提出了一個簡要回顧AMD和審查的miRNA和調節這些過程所涉及的其他非編碼的RNA參與的病理過程。
具體來說，我們討論了幾個候選的miRNA表明的承諾，作為AMD的治療目標由於其直接參與脈絡膜新生血管或視網膜色素上皮細胞萎縮。我們討論了AMD基於miRNA的潛在治療和分娩方式，並提供給AMD方面的miRNA研究領域的未來發展方向。我們相信miRNA的療法在AMD的未來是大有希望的。