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中華民國視網膜色素病變協會
:::左側區塊

RP的退化就是受到自由基的攻擊

發佈日期:2018/04/19

內容:
大家早安,今天要和大家聊聊自由基,自由基是在氧化過程中產生的,而RP的退化就是受到自由基的攻擊,因此如何抗氧化就是我們要學習的功課,像是平常可以多吃抗氧化的食材,不抽菸、不熬夜,在這裡也要提醒有服用抗氧化劑的會員,一定要記得搭配運動效果會更好喔~下面是一篇有關薑黃素治療視網膜病變的文章,可惜的是目前只有動物研究,且直接服用薑黃在人體的利用度不大,我們來看看文章怎麼說吧~~~

薑黃素在視網膜病變中的治療潛力。
由於視網膜富含血液供應、眾多的線粒體以及光線的照射使其不斷暴露於自由基下。
自由基直接或間接影響了視網膜的發炎、細胞凋亡或血管生成。由於發炎和氧化應激途徑是視網膜發病的基礎,因此解決這些造成發病的因素是一項治療的選擇。
薑黃素(diferuloylmethane)是印度香料薑黃的化合物,已被發現有效預防和治療發炎病症和腫瘤過程。薑黃素通過調節許多生物化學介質,發揮作用對抗炎症、腫瘤、抗氧化劑和VEGF抑制性質,這使薑黃素在視網膜疾病中特別有效。
結果:薑黃素在某些病例中可以減緩,甚至可以逆轉老年性性黃斑部病變,糖尿病視網膜病變,視網膜色素病變,增殖性玻璃體視網膜病和視網膜癌。
然而,關於薑黃素療效的研究主要限於動物研究。 此外,考慮到薑黃素的低溶解度和口服生物利用度,使薑黃素不容易使用 - 因此奈米顆粒和脂質體的潛力受到更多關注。
3. Int Ophthalmol. 2018 Feb 5. doi: 10.1007/s10792-018-0845-y. [Epub ahead of print]
Therapeutic potential of curcumin in major retinal pathologies.
Peddada KV(1), Brown A(2), Verma V(3), Nebbioso M(4).
Author information:
(1)Department of Ophthalmology, Drexel University, Philadelphia, PA, USA.
(2)Emory Eye Center, Emory University, Atlanta, GA, USA.
(3)Department of Radiation Oncology, University of Nebraska Medical Center,
Omaha, NE, USA.
(4)Department of Sense Organs, Ocular Electrophysiology Center, Sapienza
University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
marcella.nebbioso@uniroma1.it.
PURPOSE: The retina is continually exposed to free radicals from its rich blood
supply, numerous mitochondria, and photons of light which strike its surface.
Most pathological processes that take place in the retina, such as inflammation,
cell apoptosis, or angiogenesis, can hence involve free radicals directly or
indirectly. Since inflammatory and oxidative stress pathways underlie retinal
pathology, compounds that address these factors are therefore natural choices for
treatment. This review article summarizes and provides commentary on curcumin`s
therapeutic potential use in ophthalmology with principal focus on retinal
dosorders.
METHODS: Curcumin (diferuloylmethane) is a compound of the Indian spice turmeric
(Curcuma longa) that has been found to be efficacious in preventing and treating
a number of inflammatory diseases and neoplastic processes. Curcumin exerts
anti-inflammatory, anti-tumor, antioxidant, and VEGF inhibition properties
through modulation of numerous biochemical mediators. This makes curcumin
particularly effective in retinal disorders.
RESULTS: Curcumin has found a role in slowing, and in some cases even reversing,
age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa,
proliferative vitreoretinopathy, and retinal cancers.
CONCLUSIONS: However, studies on curcumin`s efficacy have been limited mostly to
animal studies. Moreover, the biomedical potential of curcumin is not easy to
use, given its low solubility and oral bioavailability-more attention therefore
has been given to nanoparticles and liposomes.
DOI: 10.1007/s10792-018-0845-y
PMID: 29404861